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Accutane (ISOTRETINOIN) is a drug used for the treatment of severe, disfiguring cystic acne that has not cleared up in response to milder medications such as antibiotics.
It works on the oil glands within the skin, shrinking them and diminishing their output. Accutane derives from vitamin A and is found in small quantities naturally in the body.

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Before using Accutane :

Some medical conditions may interact with Accutane . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you are woman and unable to use 2 effective forms of birth control or avoid sexual intercourse
if you have diabetes, a family history of diabetes, high blood cholesterol or triglyceride levels, psychiatric disorders, suicidal thoughts, liver disease, pancreatitis, a bone loss condition (eg, osteoporosis), decreased bone density, an eating disorder, severe diarrhea, rectal bleeding, hearing problems, ringing in the ears, or stomach pain

Some MEDICINES MAY INTERACT with Accutane . Tell your health care provider if you are taking any other medicines, especially any of the following:
Tetracyclines because the risk of increased pressure in the brain may be increased
St. John's wort because an increased risk of failure of hormonal contraceptives (eg, birth control pills) may occur
Vitamin A-type medicines (eg, etretinate, vitamin A) because they may increase the risk of Accutane 's side effects
Corticosteroids (eg, prednisone) or phenytoin because the risk of their side effects may be increased by Accutane
Progestin-only birth control (eg, "mini-pill") because its effectiveness may be decreased by Accutane

This may not be a complete list of all interactions that may occur. Ask your health care provider if Accutane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Accutane :

Use Accutane as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Accutane comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Accutane refilled.
Take Accutane by mouth with food.
Swallow the capsule with a full glass of water or other liquid. Do not break, crush, chew, or suck on the capsule before swallowing. This will help prevent the medication inside the capsule from irritating your throat.
For best results, take Accutane regularly. Taking Accutane at the same time each day will help you remember to take it.
Accutane can only be dispensed through a special program. You must sign a consent form stating that you will follow your doctor's instructions before you can take Accutane . This will be necessary each time you refill your prescription.
You will get no more than a 30-day supply of Accutane at a time to be sure you check in with your doctor each month to discuss side effects.
If you miss a dose of Accutane , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Accutane .
Important safety information:
Accutane may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Accutane with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
A sudden decrease in night vision may occur while you are taking Accutane . Use caution when driving at night and avoid driving at night if you experience decreased night vision.
If you wear contact lenses, you may have difficulty wearing them during and after therapy.
Do not give blood while taking Accutane and for 1 month after stopping taking Accutane .
Do not drink alcohol while taking Accutane .
Worsening of acne may occur during the first part of therapy. This does not suggest failure or a need to stop the medicine.
To prevent cracking of lips, use a lip moisturizer or balm.
Do not have cosmetic procedures to smooth your skin, including waxing, dermabrasion, or laser procedures, while you are taking Accutane and for at least 6 months after you stop. Accutane can increase your chance of scarring from these procedures.
Accutane may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Accutane . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
Some patients, while taking Accutane or soon after stopping it, have become depressed or developed serious mental problems. Stop using Accutane and tell your health care provider right away if you have any of these symptoms: feeling sad or having crying spells; feeling anxious; becoming more irritable, angry, or aggressive than usual; losing pleasure or interest in social or sports activities; sleeping too much or too little; changes in weight or appetite; feeling like you have no energy; having trouble concentrating; having thoughts about taking your own life or hurting yourself (suicidal thoughts).

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